Contract Research Services
Expert Services Across the Drug Development Continuum
From early-stage synthesis support to commercial-scale purification, PuriSpec delivers precision chromatographic and spectroscopic solutions tailored to your project needs.
API Synthesis Support
Expert synthetic chemistry support for active pharmaceutical ingredient development, from route scouting through multi-gram scale preparation.
- Route scouting and synthetic strategy development
- Multi-step synthesis of complex natural product-derived APIs
- Chiral building block preparation and stereochemical control
- Gram to multi-hundred gram scale synthesis
- Reaction optimization and impurity profiling
Chiral & Achiral Separations
High-resolution chiral and achiral chromatographic separations using SFC, HPLC, and preparative LC platforms to deliver enantiomerically pure compounds.
- Analytical and preparative chiral SFC/HPLC method development
- Enantiomeric excess (ee) determination and purity analysis
- Achiral reversed-phase and normal-phase separations
- Milligram to multi-gram preparative separations
- Column and solvent system screening across 20+ chiral stationary phases
Supercritical Fluid Chromatography (SFC)
State-of-the-art SFC capabilities for rapid, green, and high-throughput separations — ideal for chiral resolution and achiral purification of pharmaceutical intermediates.
- Analytical SFC method development and validation
- Preparative SFC purification from milligrams to hundreds of grams
- Stacked injection and recycling for maximum throughput
- CO₂-based mobile phases — reduced solvent waste vs. HPLC
- Coupling to MS detection for real-time fraction analysis
Spectroscopic Solutions
Comprehensive structural characterization and spectroscopic analysis to confirm identity, purity, and stereochemistry of synthesized and purified compounds.
- NMR-based structural elucidation (1H, 13C, 2D experiments)
- High-resolution mass spectrometry (HRMS) and LC-MS analysis
- Optical rotation and circular dichroism for stereochemical assignment
- Purity assessment by HPLC-UV and ELSD
- Full analytical reporting packages for regulatory submissions
Process Development & Scale-Up
Seamless transition from discovery-scale separations to process-scale manufacturing, with full documentation and technology transfer support.
- Process chemistry optimization for cost-effective scale-up
- Preparative SFC and HPLC scale-up from grams to kilograms
- Impurity identification and control strategy development
- Technology transfer documentation and SOPs
- CMO liaison and manufacturing support
Chromatography Product Marketing Support
Leverage our deep SFC and chiral chromatography expertise to support the development, validation, and positioning of chromatographic columns, instruments, and consumables.
- Application development for new chiral stationary phases
- Benchmark testing and competitive column evaluation
- Technical content creation: application notes, posters, webinars
- Customer-facing method demonstrations and training
- Scientific advisory for product roadmap and market positioning
How We Work With You
Project Scoping
We begin with a detailed consultation to understand your compound, timeline, purity requirements, and regulatory context.
Method Development
Our team designs and screens separation or synthesis strategies, selecting optimal conditions for your specific molecule.
Execution & Analysis
Separations and syntheses are performed with rigorous in-process monitoring and full spectroscopic characterization.
Delivery & Reporting
You receive purified material with a complete analytical data package — CoA, NMR, MS, and chromatographic purity data.
Ready to Discuss Your Project?
Tell us about your compound and timeline. Our team will respond within one business day.